Abstract: Recent years, intraocular antiangiogenic research is still being the hot spot in the treatment of neovascularization. Intussusceptive angiogenesis, as a special type of neovascularization, is becoming the main direction of angiogenesis research. Intussusceptive angiogenesis is confirmed to have an important effect on the growth and rebuilding of intraocular neovascularization. Different from sprouting, intussusceptive angiogenesis has no vascular basement membrane damage and endothelial cell proliferation; therefore, there is no negative phenomenon such as leakage and bleeding. By reason of repeated exudation, bleeding, scarring and visual impairment which are caused by intraocular neovascular disorders, intussusceptive angiogenesis brings new thoughts for the treatment of intraocular neovascularization.   (Int Rev Ophthalmol, 2015, 39：107-111)